Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection.

@article{Sugamata2012ContributionON,
  title={Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection.},
  author={Ryuichi Sugamata and Hideki Dobashi and Tomokazu Nagao and Ki-ichi Yamamoto and Noriko Nakajima and Yuko Sato and Yasuaki Aratani and Masamichi Oshima and Tetsutaro Sata and Kazuo Kobayashi and Shoji Settsu-shi Kawachi and Toshinori Nakayama and Kazuo Suzuki},
  journal={Microbiology and immunology},
  year={2012},
  volume={56 3},
  pages={
          171-82
        }
}
Because the pathogenesis of acute respiratory distress syndrome (ARDS) induced by influenza virus infection remains unknown, we can only improve on existing therapeutic interventions. To approach the subject, we investigated immunological etiology focused on cytokines and an acute lung damage factor in influenza-induced ARDS by using a PR-8 (A/H1N1)-infected mouse model. The infected mouse showed fulminant severe pneumonia with leukocyte infiltration, claudin alteration on tight junctions, and… CONTINUE READING
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