Contribution of mitochondrial network dynamics to intracellular ROS signaling.

  title={Contribution of mitochondrial network dynamics to intracellular ROS signaling.},
  author={Junseong Park and Chulhee Choi},
  journal={Communicative & integrative biology},
  volume={5 1},
Oxidative stresses can induce rapid depolarization of inner mitochondrial membrane potential and subsequent impairment of oxidative phosphorylation. Damaged mitochondria produce more reactive oxygen species (ROS), particularly the superoxide anion (O2-) and hydrogen peroxide (H(2)O(2)), which potentiate mitochondria-driven ROS propagation, so-called ROS-induced ROS release (RIRR), via activation of an inter-mitochondrial signaling network. In this context, mitochondrial network dynamics, such… CONTINUE READING


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