Contribution of lysophosphatidylcholine-treated nonadherent cells to mechanism of macrophage activation.

@article{Ngwenya1990ContributionOL,
  title={Contribution of lysophosphatidylcholine-treated nonadherent cells to mechanism of macrophage activation.},
  author={Benjamin Z. Ngwenya and Nobuto Yamamoto},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1990},
  volume={193 2},
  pages={
          118-24
        }
}
Lysophosphatidylcholine (lyso-PC), a product of inflammation, stimulates (in vivo) mouse peritoneal macrophages to ingest target cells via Fc receptors. In vitro treatment of macrophages with lyso-Pc was unable to enhance ingestion activity. When a mixture of macrophages and nonadherent (B and T) cells was treated with 20 micrograms of lyso-Pc/ml for 30 min, a greatly enhanced Fc-mediated ingestion was observed at about 3 hr after treatment, suggesting that nonadherent cells contributed to… CONTINUE READING
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