Contribution of lipase deficiency to mitochondrial dysfunction and insulin resistance in hMADS adipocytes

Abstract

Background/Objectives:Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are key enzymes involved in intracellular lipid catabolism. We have previously shown decreased expression and activity of these lipases in adipose tissue of obese insulin resistant individuals. Here we hypothesized that lipase deficiency might impact on insulin… (More)
DOI: 10.1038/ijo.2015.211

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