Contribution of linker stability to the activities of anticancer immunoconjugates.

Abstract

The linker component of antibody-drug conjugates (ADC) is a key feature in developing optimized therapeutic agents that are highly active at well tolerated doses. For maximal intratumoral drug delivery, linkers are required that are highly stable in the systemic circulation, yet allow for efficient drug release at the target site. In this respect, amide… (More)
DOI: 10.1021/bc7004329

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