Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis.

@article{Allahverdian2014ContributionOI,
  title={Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis.},
  author={Sima Allahverdian and Ali Cyrus Chehroudi and Bruce McManus and Thomas Abraham and Gordon A. Francis},
  journal={Circulation},
  year={2014},
  volume={129 15},
  pages={1551-9}
}
BACKGROUND Intimal smooth muscle cells (SMCs) contribute to the foam cell population in arterial plaque, and express lower levels of the cholesterol exporter ATP-binding cassette transporter A1 (ABCA1) in comparison with medial arterial SMCs. The relative contribution of SMCs to the total foam cell population and their expression of ABCA1 in comparison with intimal monocyte-derived macrophages, however, are unknown. Although the expression of macrophage markers by SMCs following lipid loading… CONTINUE READING

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