Contribution of intestinal cytochrome p450-mediated metabolism to drug-drug inhibition and induction interactions.

@article{Galetin2010ContributionOI,
  title={Contribution of intestinal cytochrome p450-mediated metabolism to drug-drug inhibition and induction interactions.},
  author={Aleksandra Galetin and Michael Gertz and J. Brian Houston},
  journal={Drug metabolism and pharmacokinetics},
  year={2010},
  volume={25 1},
  pages={28-47}
}
Current drug-drug interaction (DDI) prediction models incorporate intestinal interaction as the ratio of the intestinal availability in the presence and absence of an inhibitor/inducer (F(G)' and F(G), respectively). The incorporation of the gut is commonly associated with a reduced number of false negative predictions; however, in some instances a trend for over-prediction is apparent. This differential success is highly dependent on the initial model assumptions and parameter estimates used… CONTINUE READING

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