Contribution of interferon-beta to the immune activation induced by double-stranded DNA.

@article{Shirota2006ContributionOI,
  title={Contribution of interferon-beta to the immune activation induced by double-stranded DNA.},
  author={Hidekazu Shirota and Ken J Ishii and Hiroki Takakuwa and Dennis M Klinman},
  journal={Immunology},
  year={2006},
  volume={118 3},
  pages={302-10}
}
Introducing double-stranded DNA (dsDNA) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (APCs). This process is characterized by the up-regulation of costimulatory molecules and the production of various cytokines, chemokines, and antibacterial/viral factors. Current findings indicate that interferon-beta (IFN-beta) plays a key role in the stimulatory cascade triggered by dsDNA. Both immune and non-immune cells respond… CONTINUE READING

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