Contribution of insertions and deletions to the variability of hepatitis C virus populations.

@article{TorresPuente2007ContributionOI,
  title={Contribution of insertions and deletions to the variability of hepatitis C virus populations.},
  author={Manuela Torres-Puente and Jose Cuevas and Nuria Jim{\'e}nez-Hern{\'a}ndez and M. Bracho and Inmaculada Garc{\'i}a-Robles and Fernando Carnicer and Juan Manuel Decara del Olmo and Enrique Ortega and Andr{\'e}s Moya and Fernando Gonz{\'a}lez-Candelas},
  journal={The Journal of general virology},
  year={2007},
  volume={88 Pt 8},
  pages={2198-203}
}
Little is known about the potential effects of insertions and deletions (indels) on the evolutionary dynamics of hepatitis C virus (HCV). In fact, the consequences of indels on antiviral treatment response are a field of investigation completely unexplored. Here, an extensive sequencing project was undertaken by cloning and sequencing serum samples from 25 patients infected with HCV subtype 1a and 48 patients with subtype 1b. For 23 patients, samples obtained after treatment with alpha… CONTINUE READING
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