Contribution of individual organ mass loss to weight loss-associated decline in resting energy expenditure.

@article{BosyWestphal2009ContributionOI,
  title={Contribution of individual organ mass loss to weight loss-associated decline in resting energy expenditure.},
  author={Anja Bosy-Westphal and Elke Kossel and Kristin Goele and Wiebke Later and Britta Hitze and Uta Settler and Martin Heller and Claus C. Gl{\"u}er and Steven B. Heymsfield and Manfred J. M{\"u}ller},
  journal={The American journal of clinical nutrition},
  year={2009},
  volume={90 4},
  pages={
          993-1001
        }
}
BACKGROUND Weight loss leads to reduced resting energy expenditure (REE) independent of fat-free mass (FFM) and fat mass (FM) loss, but the effect of changes in FFM composition is unclear. OBJECTIVE We hypothesized that a decrease in REE adjusted for FFM with weight loss would be partly explained by a disproportionate loss in the high metabolic activity component of FFM. DESIGN Forty-five overweight and obese women [body mass index (in kg/m(2)): 28.7-46.8] aged 22-46 y followed a low… 
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136 Citations
Highly Influential Citations
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Methods Citations
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136 Citations

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Impact of body composition during weight change on resting energy expenditure and homeostasis model assessment index in overweight nonsmoking adults.
TLDR
Beyond a 2-compartment model, detailed changes in organ and tissue masses further add to explain changes in REE and insulin resistance.
Issues in characterizing resting energy expenditure in obesity and after weight loss
TLDR
The most established method for normalization of REE based on FFM and FM may lead to spurious conclusions about metabolic rate in obesity and the phenomenon of weight loss-associated adaptive thermogenesis.
Effect of weight loss and regain on adipose tissue distribution, composition of lean mass and resting energy expenditure in young overweight and obese adults
TLDR
Weight loss-associated adaptations in REE may impair weight loss and contribute to weight regain, and weight regain did not adversely affect body fat distribution.
Impact of Fat-Free Mass Quality and Detailed Body Composition on Changes of Resting Energy Expenditure with Age
TLDR
Age-related changes in body composition explain most of the variance in metabolic changes in resting energy expenditure (REE) and fat-free mass (FFM), and the variances in REE are associated with health.
Age-Dependent Changes in Resting Energy Expenditure (REE): Insights from Detailed Body Composition Analysis in Normal and Overweight Healthy Caucasians
TLDR
Differences between REE and REEc increased with age, suggesting age-related changes in specific metabolic rates of organs and tissues, and age-dependent changes in the REE-FFMassociation are explained by composition of FFM, inflammation and thyroid hormones.
Resting Energy Expenditure and Organ-Tissue Body Composition 5 Years After Bariatric Surgery
TLDR
Post bariatric surgery patients maintain a larger mass of high–metabolic rate trunk organs than non-operated controls of similar anthropometrics andInterpreting REE changes after weight loss requires an accurate understanding of fat-free mass composition at both the organ and tissue levels.
Examining the effects of weight loss on energy expenditure in humans
TLDR
This analysis provides more evidence in favour of adaptive modifications during weight loss that result in greater than expected decreases in resting EE than can be predicted through changes in FM and FFM alone.
Tissue losses and metabolic adaptations both contribute to the reduction in resting metabolic rate following weight loss
TLDR
It is not skeletal muscle, but rather adipose tissue losses that seem to drive RMR reductions following weight loss, and future research should target personalized strategies addressing the predominant cause of RMR reduction for weight maintenance.
Changes in leptin and peptide YY do not explain the greater-than-predicted decreases in resting energy expenditure after weight loss.
TLDR
The relationships between leptin, PYY, and body composition with different EE components before and after weight loss and whether changes in leptin and PYY were associated with differences in predicted vs measured REE after the intervention were examined.
Dynamic changes in energy expenditure in response to underfeeding: a review.
TLDR
By simulating dynamic changes in energy expenditure associated with underfeeding, mathematical modelling may provide a more accurate method of weight-loss prediction, as accuracy at an individual level is limited due to difficulty estimating energy requirements, physical activity and dietary intake in free-living individuals.
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References

SHOWING 1-10 OF 58 REFERENCES
Body-size dependence of resting energy expenditure can be attributed to nonenergetic homogeneity of fat-free mass.
TLDR
The hypothesis that FFM varies systematically in the proportion of thermogenic components as a function of body mass and FFM can be explained by a larger proportion of FFM as high-metabolic-rate tissues compared with that observed in heavier subjects is tested.
Effect of organ and tissue masses on resting energy expenditure in underweight, normal weight and obese adults
TLDR
Detailed analysis of metabolically active components of FFM allows REE prediction over a wide range ofFFM and provides indirect evidence for a view that, for practical purposes within humans, the specific metabolic rate is constant with increasing organ mass.
Metabolically active components of fat free mass and resting energy expenditure in nonobese adults.
TLDR
The mass of internal organs contributes significantly to the variance in REE, and the very close agreement between measured and predicted REE argues against significant variations in specific REEs of individual organs.
Influence of methods used in body composition analysis on the prediction of resting energy expenditure
TLDR
Differences in slopes and intercepts of the regression lines between REE and FFM depended on the methods used for body composition analysis, which imply a population- and/or investigator specificity of algorithms for REE prediction.
Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change.
TLDR
On the average, spontaneous long term weight changes are accompanied by small metabolic adaptations in both energy expenditure and fat oxidation, however, the metabolic responses to weight change are highly variable among individuals.
Larger mass of high-metabolic-rate organs does not explain higher resting energy expenditure in children.
TLDR
The decline in REE during growth is likely due to both a decrease in the proportion of some of the more metabolically active organs and tissues and changes in the metabolic rate of individual organs and tissue.
Grade of adiposity affects the impact of fat mass on resting energy expenditure in women
TLDR
The data suggest that the specific metabolic rate of fat tissue is reduced at high adiposity, which should be considered when REE is normalized for FM in obesity.
Changes in energy expenditure resulting from altered body weight.
TLDR
Maintenance of a reduced or elevated body weight is associated with compensatory changes in energy expenditure, which oppose the maintenance of a body weight that is different from the usual weight, which may account for the poor long-term efficacy of treatments for obesity.
Reduced rate of energy expenditure as a risk factor for body-weight gain.
TLDR
It is concluded that a low rate of energy expenditure may contribute to the aggregation of obesity in families.
Influence of distribution of lean body mass on resting metabolic rate after weight loss and weight regain: comparison of responses in white and black women.
TLDR
In both races, trunk LBM decreased with weight loss and remained lower, despite significant weight regain, which potentially reflected decreased organ mass.
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