Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.

@article{Yu2003ContributionOI,
  title={Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.},
  author={A E Yu and Jeffrey R Idle and Kristopher W. Krausz and Adrian K{\"u}pfer and Frank J. Gonzalez},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={305 1},
  pages={315-22}
}
The psychotropic beta-carboline alkaloids, showing high affinity for 5-hydroxytryptamine, dopamine, benzodiazepine, and imidazoline receptors and the stimulation of locus coeruleus neurons, are formed endogenously from tryptophan-derived indolealkylamines through the Pictet-Spengler condensation with aldehydes in both plants and mammals. Cytochromes P450 1A1 (18.5), 1A2 (20), and 2D6 (100) catalyzed the O-demethylation of harmaline, and CYP1A1 (98.5), CYP1A2 (35), CYP2C9 (16), CYP2C19 (30), and… CONTINUE READING

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