Contribution of human bone marrow stem cells to individual skeletal myotubes followed by myogenic gene activation.

@article{Lee2005ContributionOH,
  title={Contribution of human bone marrow stem cells to individual skeletal myotubes followed by myogenic gene activation.},
  author={Jee Hyung Lee and Penelope A Kosinski and Daniel M. Kemp},
  journal={Experimental cell research},
  year={2005},
  volume={307 1},
  pages={174-82}
}
Much attention is focused on characterizing the contribution of bone marrow (BM)-derived cells to regenerating skeletal muscle, fuelled by hopes for stem cell-mediated therapy of muscle degenerative diseases. Though physical integration of BM stem cells has been well documented, little evidence of functional commitment to myotube phenotype has been reported. This is due to the innate difficulty in distinguishing gene products derived from donor versus host nuclei. Here, we demonstrate that BM… CONTINUE READING
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