Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor.

  title={Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor.},
  author={Linqi Zhang and Wenjie Yu and Tian Jin He and Jian-jun Yu and Rebecca E. Caffrey and Enrique A. Dalmasso and Siyu Fu and Thang Van Pham and Jianfeng Mei and Jaclyn J. Ho and Wenyong Zhang and Peter Lopez and David D. Ho},
  volume={298 5595},
It has been known since 1986 that CD8 T lymphocytes from certain HIV-1-infected individuals who are immunologically stable secrete a soluble factor, termed CAF, that suppresses HIV-1 replication. However, the identity of CAF remained elusive despite an extensive search. By means of a protein-chip technology, we identified a cluster of proteins that were secreted when CD8 T cells from long-term nonprogressors with HIV-1 infection were stimulated. These proteins were identified as alpha-defensin… CONTINUE READING
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