Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone.

@article{Gorski1997ContributionOH,
  title={Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone.},
  author={Jude Christopher Gorski and David R. Jones and Steven A. Wrighton and Stephen D. Hall},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1997},
  volume={27 3},
  pages={243-56}
}
1. The capability of human CYPs other than 2E1 to catalyse the formation of 6-hydroxychlorzoxazone (6OHCHZ) was examined in vitro using human liver microsomes. 2. 4-Methylpyrazole, diethyldithiocarbamate (DDC), and rabbit anti-human CYP2E1 antibodies reduced chlorzoxazone 6-hydroxylase activity by 60, 60 and 50% respectively. The rate of formation of 6OHCHZ by DDC-treated microsomes was reduced further by the 3A inhibitors midazolam, troleandomycin and gestodene and increased by alpha… CONTINUE READING

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