Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes.

@article{Brenot2004ContributionOG,
  title={Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes.},
  author={Audrey Brenot and K. Y. King and Blythe E. Janowiak and Owen W. Griffith and Michael G Caparon},
  journal={Infection and immunity},
  year={2004},
  volume={72 1},
  pages={408-13}
}
Glutathione peroxidases are widespread among eukaryotic organisms and function as a major defense against hydrogen peroxide and organic peroxides. However, glutathione peroxidases are not well studied among prokaryotic organisms and have not previously been shown to promote bacterial virulence. Recently, a gene with homology to glutathione peroxidase was shown to contribute to the antioxidant defenses of Streptococcus pyogenes (group A streptococcus). Since this bacterium causes numerous… CONTINUE READING

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The fact that genes encoding putative glutathione peroxidases are found in the genomes of many pathogenic bacterial species suggests that glutathione peroxidase may have a general role in bacterial pathogenesis .
Glutathione peroxidases are widespread among eukaryotic organisms and function as a major defense against hydrogen peroxide and organic peroxides .
The fact that genes encoding putative glutathione peroxidases are found in the genomes of many pathogenic bacterial species suggests that glutathione peroxidase may have a general role in bacterial pathogenesis .
Glutathione peroxidases are widespread among eukaryotic organisms and function as a major defense against hydrogen peroxide and organic peroxides .
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