Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer

@article{Rummel2017ContributionOG,
  title={Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer},
  author={Seth K. Rummel and Leann Lovejoy and Craig D. Shriver and Rachel E. Ellsworth},
  journal={Breast Cancer Research and Treatment},
  year={2017},
  volume={164},
  pages={593-601}
}
Although breast cancer in young women accounts for <10% of diagnoses annually, tumors in young patients exhibit more aggressive characteristics and higher mortality rates. Determination of the frequency of germline mutations in cancer predisposition genes is needed to improve the understanding of breast cancer etiology in young women. All female patients enrolled in the Clinical Breast Cancer Project between 2001 and 2015 and diagnosed with invasive breast cancer before age 40 were included in… CONTINUE READING
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