Contribution of genetic variants to pain susceptibility in Parkinson disease

@article{Greenbaum2012ContributionOG,
  title={Contribution of genetic variants to pain susceptibility in Parkinson disease},
  author={L. Greenbaum and I. Tegeder and Y. Barhum and E. Melamed and Y. Roditi and R. Djaldetti},
  journal={European Journal of Pain},
  year={2012},
  volume={16}
}
Pain is a one of the most disturbing non‐motor symptoms of Parkinson disease (PD). The susceptibility to pain varies substantially among patients with PD. The aim of this study was to assess a potential association of genetic variants to PD‐related pain. 
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References

SHOWING 1-10 OF 49 REFERENCES
Pain in Parkinson's disease
TLDR
The many causes of pain with Parkinson's disease, which include disease complications and primary sensory pain syndromes, are discussed and the treatment options available are evaluated. Expand
Pain in Parkinson's disease
  • B. Ford
  • Medicine
  • Movement disorders : official journal of the Movement Disorder Society
  • 2010
TLDR
A framework for diagnosing and treating painful PD is described in this review, together with recent insignts into the neurophysiological mechanisms and substrates of pain in PD. Expand
Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain
To assess the genetic association of pain in patients with knee osteoarthritis (OA) and those with multiple regional pain with the R1150W variant in the α‐subunit of the voltage‐gated sodium channelExpand
The Threshold of Pain and Neurotransmitter's Change on Pain in Parkinson's Disease
TLDR
Results suggest that decreases in the threshold of pain and changes of serotonin in CSF are involved in the development of specific pain in PD who do not respond to L‐dopa. Expand
Pain in Parkinson’s disease: Prevalence and characteristics
TLDR
Pain is frequent and disabling, independent of demographic and clinical variables except for female gender, and is significantly more common in Parkinson’s patients compared to the general population and is not associated with age, disease duration or severity of the disease. Expand
Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment
TLDR
The dopaminergic basis of the range of non-motor symptoms that occur in PD such as depression, apathy, sleep disorders (including rapid-eye movement sleep behaviour disorder), and erectile dysfunction are investigated. Expand
Pain perception is altered by a nucleotide polymorphism in SCN9A
TLDR
It is concluded that individuals experience differing amounts of pain, per nociceptive stimulus, on the basis of their SCN9A rs6746030 genotype. Expand
Levodopa raises objective pain threshold in Parkinson’s disease: a RIII reflex study
TLDR
Evidence of a dopaminergic modulation of objective pain threshold in Parkinson’s disease patients is provided and the decrease in RIII threshold in PD patients, in the OFF condition, compared with controls, confirms the existence of an objective pain perception disturbance in PD. Expand
Nonmotor symptoms as presenting complaints in Parkinson's disease: A clinicopathological study
TLDR
Nonmotor symptoms are commonly seen as presenting complaints in pathologically confirmed PD, and initial misdiagnosis may be associated with potentially inappropriate medical interventions. Expand
Genetic basis for individual variations in pain perception and the development of a chronic pain condition.
TLDR
Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD. Expand
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