Contribution of genetic factors to platinum-based chemotherapy sensitivity and prognosis of non-small cell lung cancer.

@article{PrezRamrez2017ContributionOG,
  title={Contribution of genetic factors to platinum-based chemotherapy sensitivity and prognosis of non-small cell lung cancer.},
  author={Cristina P{\'e}rez-Ram{\'i}rez and Marisa Ca{\~n}adas-Garre and Miguel {\'A}ngel Molina and Ana I Robles and Mar{\'i}a Jos{\'e} Faus-D{\'a}der and Miguel-{\'A}ngel Calleja-Hern{\'a}ndez},
  journal={Mutation research},
  year={2017},
  volume={771},
  pages={32-58}
}
Although platinum-based chemotherapy remains the standard treatment for advanced NSCLC patients, clinical outcomes are poor and most patients develop high-grade toxicities. Genetic factors, such as single nucleotide polymorphisms (SNPs) involved in platinum pharmacodynamics, metabolism and mechanism of action, may account for inter-individual differences… CONTINUE READING