Contribution of genetic and nutritional factors to DNA damage in heavy smokers.

  title={Contribution of genetic and nutritional factors to DNA damage in heavy smokers.},
  author={LaVerne A Mooney and Douglas A. Bell and Regina M. Santella and Ari{\"e}tte M van Bennekum and Ruth Ottman and Myunghee Paik and William S. Blaner and George W. Lucier and Lirio Covey and Tie Lan Young and Thomas B. Cooper and Alexander H. Glassman and Frederica Perera},
  volume={18 3},
Prior epidemiological evidence suggests that genes controlling the metabolism of carcinogens and antioxidant/nutritional status are associated with lung cancer risk, possibly through their ability to modulate DNA damage by carcinogens. We performed a cross-sectional analysis of 159 heavy smokers from a cohort of subjects enrolled in a smoking cessation program. A total of 159 blood samples were analyzed to determine the relative contributions of genetic polymorphisms [CYP1A1 MspI and exon 7 and… CONTINUE READING


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