Contribution of gene expression to metabolic fluxes in hypermetabolic livers induced through burn injury and cecal ligation and puncture in rats.

@article{Banta2007ContributionOG,
  title={Contribution of gene expression to metabolic fluxes in hypermetabolic livers induced through burn injury and cecal ligation and puncture in rats.},
  author={Scott Banta and Murali Vemula and Tadaaki Yokoyama and Arul Jayaraman and Francois Berthiaume and Martin L. Yarmush},
  journal={Biotechnology and bioengineering},
  year={2007},
  volume={97 1},
  pages={118-37}
}
Severe injury activates many stress-related and inflammatory pathways that can lead to a systemic hypermetabolic state. Prior studies using perfused hypermetabolic rat livers have identified intrinsic metabolic flux changes that were not dependent upon the continual presence of elevated stress hormones and substrate loads. We investigated the hypothesis that such changes may be due to persistent alterations in gene expression. A systemic hypermetabolic response was induced in rats by applying a… CONTINUE READING

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