Contribution of functional groups of 19-nor-progestogens to binding to progesterone and estradiol-17beta receptors in rabbit uterus.

@article{Tamaya1977ContributionOF,
  title={Contribution of functional groups of 19-nor-progestogens to binding to progesterone and estradiol-17beta receptors in rabbit uterus.},
  author={Teruhiko Tamaya and Shoko Nioka and Nozomu Furuta and Takesada Shimura and Nariko Takano},
  journal={Endocrinology},
  year={1977},
  volume={100 6},
  pages={
          1579-84
        }
}
The structural elements of 19-norprogestogens which may be essential for binding to progesterone and estradiol-17beta(E2) receptors were investigated in the rabbit uterine cytosol. The kinetic study showed that 19-nor-progestogens are competitive inhibitors of progesterone-receptor (8S) binding and E2-receptor binding. The affinities of steroids for the progesterone receptor were as follows: norethindrone (Ki of 2.3 X 10(-9)M) greater than 5alpha-dihydronorethindrone greater than norethindrone… CONTINUE READING

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