Contribution of frontostriatal function to sequence learning in Parkinson's Disease: evidence for dissociable systems

@article{Dominey1997ContributionOF,
  title={Contribution of frontostriatal function to sequence learning in Parkinson's Disease: evidence for dissociable systems},
  author={Peter Ford Dominey and Marc Jeannerod},
  journal={NeuroReport},
  year={1997},
  volume={8},
  pages={iii–ix}
}
THE frontostriatal system appears to play a crucial role in the organization and execution of sequential behaviour, but the precise nature of its contribution remains to be specified. From this perspective, relatively simple modifications of behavioural task parameters may invoke rather profound changes in the recruitment of appropriate neural mechanisms, including the frontostriatal system. This mini-review examines how variations in task requirements for sequence learning and related… 

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References

SHOWING 1-10 OF 59 REFERENCES

Behavior and the basal ganglia.

To return to the broad principle of habituation, a process first described in the context of the visual system and its connections with the tail of the caudate nucleus, it would be tempting to view PD and OCD as disorders of "under" and "over" habituation to behavioral routines.

Attentional and Nonattentional Forms of Sequence Learning

The results suggest that attentional and nonattentional learning operate independently, in parallel, do not share information, and represent sequential information in qualitatively different ways.

Activity in the caudate nucleus of monkey during spatial sequencing.

The role of the caudate nucleus in the construction, storage, and execution of spatial plans is examined and the responses of the cells to the same instruction stimuli repeated twice in a row are tested.

Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex.

An oculomotor delayed-response task was used to examine the spatial memory functions of neurons in primate prefrontal cortex and found that inhibitory responses were usually strongest for, or centered about, cue directions roughly opposite those optimal for excitatory responses.

Characteristics of dissociable human learning systems

The distinction between instance and rule learning is a sound and meaningful way of taxonomizing human learning and various computational models of these two forms of learning are discussed.

Abnormalities of nonvisually-guided eye movements in Parkinson's disease.

The results support the view that for saccades which are not directly elicited by a visual target there is a neural pathway that can be distinguished from structures involved in the generation of visually elicited (or 'reflexive') saccade.

Sequencing in Parkinson's disease. Abnormalities in programming and controlling movement.

Central programming deficits in Parkinson's disease (PD) were studied in two reaction time (RT) experiments and PD patients' decision times improved more with a longer delay only for heterogeneous sequences, suggesting a problem in identifying the number of different hand postures.

Spatial attention and implicit sequence learning: evidence for independent learning of spatial and nonspatial sequences.

  • U. Mayr
  • Psychology, Biology
    Journal of experimental psychology. Learning, memory, and cognition
  • 1996
It is shown that the joint learning of spatial and object sequences was as efficient as learning of single sequences and that it even occurred when learning required memory for past sequence elements and attention was blocked through a secondary tone-counting task.
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