Contribution of frontostriatal function to sequence learning in Parkinson's Disease: evidence for dissociable systems

  title={Contribution of frontostriatal function to sequence learning in Parkinson's Disease: evidence for dissociable systems},
  author={Peter Ford Dominey and Marc Jeannerod},
THE frontostriatal system appears to play a crucial role in the organization and execution of sequential behaviour, but the precise nature of its contribution remains to be specified. From this perspective, relatively simple modifications of behavioural task parameters may invoke rather profound changes in the recruitment of appropriate neural mechanisms, including the frontostriatal system. This mini-review examines how variations in task requirements for sequence learning and related… 

Distinct Contribution of the Striatum and Cerebellum to Motor Learning

The present findings suggest that the striatum and cerebellum are involved in distinct learning mechanisms in patients with Parkinson's disease or with cerebellar damage and in age-matched controls.

Frontal-striatal circuit functions: Context, sequence, and consequence

  • J. Saint-Cyr
  • Psychology, Biology
    Journal of the International Neuropsychological Society
  • 2003
It is hoped that the present formulation will suggest new heuristic research strategies for basal ganglia research, permitting a closer link to be established between neurophysiological, functional imaging and neuropsychological paradigms.

Basal ganglia: Their role in complex cognitive procedures in experimental models and in clinical practice

This article traces the scientific work that explores the role of BG in reinforcement learning, perceptual decision making, and other nonmotor pathways (speech fluency, cognition, attention and behaviour) and highlights the important role played by the BG networks in determining the development of a child's brain.

Role of [corrected] nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner.

The striatum and its nigrostriatal afferents function in the initial learning underlying performance of sequences of movements as single motor programs, and lesions of the nigrostiatal system spare the ability to relearn the previously acquired programs.

The differential effect of PD and normal aging on early explicit sequence learning

Despite normal motor execution, the initial phases of sequence learning are impaired in early PD independent of task requirements, possibly reflecting reduced working memory.

Learning and retention of movement sequences in Parkinson's disease

If people with PD are given sufficient practice they can learn and retain both memory‐based and context‐driven movement sequences as well as age‐matched controls, and exhibited retention across the 3‐week retention interval.



Behavior and the basal ganglia.

To return to the broad principle of habituation, a process first described in the context of the visual system and its connections with the tail of the caudate nucleus, it would be tempting to view PD and OCD as disorders of "under" and "over" habituation to behavioral routines.

Attentional and Nonattentional Forms of Sequence Learning

The results suggest that attentional and nonattentional learning operate independently, in parallel, do not share information, and represent sequential information in qualitatively different ways.

Activity in the caudate nucleus of monkey during spatial sequencing.

The role of the caudate nucleus in the construction, storage, and execution of spatial plans is examined and the responses of the cells to the same instruction stimuli repeated twice in a row are tested.

Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex.

An oculomotor delayed-response task was used to examine the spatial memory functions of neurons in primate prefrontal cortex and found that inhibitory responses were usually strongest for, or centered about, cue directions roughly opposite those optimal for excitatory responses.

Characteristics of dissociable human learning systems

The distinction between instance and rule learning is a sound and meaningful way of taxonomizing human learning and various computational models of these two forms of learning are discussed.

Abnormalities of nonvisually-guided eye movements in Parkinson's disease.

The results support the view that for saccades which are not directly elicited by a visual target there is a neural pathway that can be distinguished from structures involved in the generation of visually elicited (or 'reflexive') saccade.

Sequencing in Parkinson's disease. Abnormalities in programming and controlling movement.

Central programming deficits in Parkinson's disease (PD) were studied in two reaction time (RT) experiments and PD patients' decision times improved more with a longer delay only for heterogeneous sequences, suggesting a problem in identifying the number of different hand postures.

Spatial attention and implicit sequence learning: evidence for independent learning of spatial and nonspatial sequences.

  • U. Mayr
  • Psychology, Biology
    Journal of experimental psychology. Learning, memory, and cognition
  • 1996
It is shown that the joint learning of spatial and object sequences was as efficient as learning of single sequences and that it even occurred when learning required memory for past sequence elements and attention was blocked through a secondary tone-counting task.