Contribution of exoenzyme S to the virulence of Pseudomonas aeruginosa.

  title={Contribution of exoenzyme S to the virulence of Pseudomonas aeruginosa.},
  author={Thalia I. Nicas and Barbara H. Iglewski},
  journal={Antibiotics and chemotherapy},
Exoenzyme S is an extracellular ADPR transferase produced by P. aeruginosa. Forms of this enzyme that have thus far been purified are not toxic, however, exoenzyme S clearly contributes to the virulence of strain 388. Thus, a Tn1 mutant deficient in exoenzyme S was found to be markedly less virulent than its exoenzyme S-producing parental strain in both a burned mouse infection model and a rat chronic lung infection model. Exoenzyme S does not appear to contribute to initial colonization of the… CONTINUE READING

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