Contribution of exoenzyme S to the virulence of Pseudomonas aeruginosa.

@article{Nicas1985ContributionOE,
  title={Contribution of exoenzyme S to the virulence of Pseudomonas aeruginosa.},
  author={Thalia I. Nicas and Barbara H. Iglewski},
  journal={Antibiotics and chemotherapy},
  year={1985},
  volume={36},
  pages={40-8}
}
Exoenzyme S is an extracellular ADPR transferase produced by P. aeruginosa. Forms of this enzyme that have thus far been purified are not toxic, however, exoenzyme S clearly contributes to the virulence of strain 388. Thus, a Tn1 mutant deficient in exoenzyme S was found to be markedly less virulent than its exoenzyme S-producing parental strain in both a burned mouse infection model and a rat chronic lung infection model. Exoenzyme S does not appear to contribute to initial colonization of the… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Severe Infections Caused by Pseudomonas Aeruginosa

Perspectives on Critical Care Infectious Diseases • 2003
View 4 Excerpts
Highly Influenced

The GAP portion of Pseudomonas aeruginosa type III secreted toxin ExoS upregulates total and surface levels of wild type CFTR.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2013

Similar Papers

Loading similar papers…