Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation.

  title={Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation.},
  author={David M. Gilligan and Julio A. Panza and Crescence M Kilcoyne and Myron A. Waclawiw and P R Casino and Arshed A Quyyumi},
  volume={90 6},
BACKGROUND Endothelium-derived nitric oxide is an important modulator of resting vascular tone in animals and humans. However, the contribution of nitric oxide to exercise-induced vasodilation is unknown. METHODS AND RESULTS The effect of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, on exercise-induced vasodilation was studied in 18 healthy subjects (mean +/- SD, 40 +/- 10 years; 10 women). Acetylcholine was used to test the efficacy of L-NMMA in inhibiting… CONTINUE READING


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