Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes.

@article{Hawkins2003ContributionOE,
  title={Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes.},
  author={Meredith Hawkins and Julia Tonelli and P. RadhaKrishna Kishore and Daniel T. Stein and Enzo Ragucci and Alon Gitig and K. Sharat Reddy},
  journal={Diabetes},
  year={2003},
  volume={52 11},
  pages={2748-58}
}
Increased circulating free fatty acids (FFAs) inhibit both hepatic and peripheral insulin action. Because the loss of effectiveness of glucose to suppress endogenous glucose production and stimulate glucose uptake contributes importantly to fasting hyperglycemia in type 2 diabetes, we examined whether the approximate twofold elevations in FFA characteristic of poorly controlled type 2 diabetes contribute to this defect. Glucose levels were raised from 5 to 10 mmol/l while maintaining fixed… CONTINUE READING
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Circulating fatty M

  • RL Dobbins, M Chester, M Daniels, D McGarry, D Stein
  • HAWKINS AND ASSOCIATES DIABETES,
  • 2003

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