Contribution of degradation products to the anticancer activity of curcumin.

  title={Contribution of degradation products to the anticancer activity of curcumin.},
  author={Liang Shen and Hong-fang Ji},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={15 22},
          7108; author reply 7108-9
To the Editors: The recent interesting article by Dhillon et al. (1) evaluated the clinical biological effects of curcumin against advanced pancreatic cancer. One important puzzle arising from this study involves how the biological activities are done with the precondition of the low nanogram levels of circulating curcumin (only 22-41 ng/mL were detectable in plasma even at oral dose of 8 g/d; ref. 1). More efforts are needed to shed new light on the pharmacology of curcumin. Curcumin possesses… CONTINUE READING


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