Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: a novel target for antihypertensive agents.

@article{Malik2012ContributionOC,
  title={Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: a novel target for antihypertensive agents.},
  author={Kafait U. Malik and Brett L. Jennings and Fariborz A. Yaghini and Seyhan Sahan-Firat and Chi Young Song and Anne M. Estes and Xiao Rong Fang},
  journal={Prostaglandins & other lipid mediators},
  year={2012},
  volume={98 3-4},
  pages={69-74}
}
The aim of this review is to discuss the contribution of cytochrome P450 (CYP) 1B1 in vascular smooth muscle cell growth, hypertension, and associated pathophysiology. CYP1B1 is expressed in cardiovascular and renal tissues, and mediates angiotensin II (Ang II)-induced activation of NADPH oxidase and generation of reactive oxygen species (ROS), and vascular smooth muscle cell migration, proliferation, and hypertrophy. Moreover, CYP1B1 contributes to the development and/or maintenance of… CONTINUE READING
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