Contribution of collagen matrix to passive left ventricular mechanics in isolated rat hearts.

@article{Mackenna1994ContributionOC,
  title={Contribution of collagen matrix to passive left ventricular mechanics in isolated rat hearts.},
  author={Deidre A Mackenna and Jeffrey H. Omens and Andrew D. McCulloch and James W. Covell},
  journal={The American journal of physiology},
  year={1994},
  volume={266 3 Pt 2},
  pages={H1007-18}
}
Although it makes up only 2-6% of left ventricular dry weight, collagen is thought to be the major structural protein determining passive ventricular stiffness. However, the relationship between structure of the extracellular matrix and passive mechanics is not understood. Hence, to deplete the collagen matrix, 16 rat hearts were perfused with bacterial collagenase for 60 min. Quantitative morphology using picrosirius red revealed a 36% decrease in collagen area fraction predominantly in the… CONTINUE READING

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