Contribution of collagen adhesion receptors to tissue fibrosis

@article{Coelho2016ContributionOC,
  title={Contribution of collagen adhesion receptors to tissue fibrosis},
  author={Nuno Miranda Coelho and C A McCulloch},
  journal={Cell and Tissue Research},
  year={2016},
  volume={365},
  pages={521-538}
}
Fibrosis is the result of a wound-healing response that fails to restore normal tissue structure function. One of the critical hallmarks of fibrosis is disrupted collagen remodeling. In tissue homeostasis, the production, deposition and organization of collagen is balanced by the degradation and remodeling of collagen within the existing matrix. After injury or chronic infection, tissues initiate a wound-healing response that is intended to create a new ECM for restoring tissue structure and… CONTINUE READING
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Integrin alpha1beta1

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