Contribution of circulating IGF-I to wound repair in GH-treated rats.

  title={Contribution of circulating IGF-I to wound repair in GH-treated rats.},
  author={Vera Dunaiski and David A. Belford},
  journal={Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society},
  volume={12 6},
Systemic administration of growth hormone (GH) stimulates granulation tissue formation, increases collagen deposition, improves the breaking strength of incisional wounds, and decreases donor-site healing times in burn patients. The possible role for circulating IGF-I in mediating this effect of growth hormone has not been investigated. To assess the relative effects of systemic IGF-I and GH on dermal repair, incisional wounds were created on the backs of male Sprague-Dawley rats treated with… CONTINUE READING
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