Contribution of chloride channel activation to the elevated muscular tone of the pulmonary artery in monocrotaline-induced pulmonary hypertensive rats.

@article{Nakazawa2001ContributionOC,
  title={Contribution of chloride channel activation to the elevated muscular tone of the pulmonary artery in monocrotaline-induced pulmonary hypertensive rats.},
  author={Hiroshi Nakazawa and M Hori and Takahisa Murata and H. Ozaki and Hideaki Karaki},
  journal={Japanese journal of pharmacology},
  year={2001},
  volume={86 3},
  pages={310-5}
}
In monocrotaline-treated rat pulmonary artery from which endothelium was removed, greater spontaneous muscular tone was observed under resting conditions than in vehicle-treated artery. The aim of the present study was to show the possible contribution of Cl- channels in the mechanism of the elevated tone. Verapamil almost completely inhibited the elevated… CONTINUE READING