Contribution of chloride channel activation to the elevated muscular tone of the pulmonary artery in monocrotaline-induced pulmonary hypertensive rats.

@article{Nakazawa2001ContributionOC,
  title={Contribution of chloride channel activation to the elevated muscular tone of the pulmonary artery in monocrotaline-induced pulmonary hypertensive rats.},
  author={Harumi Nakazawa and Masatoshi Hori and Takahisa Murata and Hiroshi Ozaki and Hideaki Karaki},
  journal={Japanese journal of pharmacology},
  year={2001},
  volume={86 3},
  pages={
          310-5
        }
}
In monocrotaline-treated rat pulmonary artery from which endothelium was removed, greater spontaneous muscular tone was observed under resting conditions than in vehicle-treated artery. The aim of the present study was to show the possible contribution of Cl- channels in the mechanism of the elevated tone. Verapamil almost completely inhibited the elevated spontaneous muscular tone by decreasing [Ca2+]i. The elevated muscular tone was also inhibited by 4,4'-diisothiocyanato-stilbene-2,2… CONTINUE READING

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