Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium.

@article{Bhm1991ContributionOC,
  title={Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium.},
  author={Michael B{\"o}hm and Ingo Morano and Burket Pieske and Johann Caspar R{\"u}egg and M. Wankerl and Ren{\'e} Zimmermann and Erland Erdmann},
  journal={Circulation research},
  year={1991},
  volume={68 3},
  pages={689-701}
}
Previous studies have shown reduced effects of cAMP-dependent positive inotropic agents in the failing human myocardium; thus other cAMP-independent mechanisms of action may be useful to increase force of contraction in this condition. The purpose of this investigation was to determine whether a positive inotropic effect of the cAMP-phosphodiesterase (PDE… CONTINUE READING