Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice

@article{Heppner2015ContributionOB,
  title={Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice},
  author={Kristy M. Heppner and Sarah A Marks and Jenna Holland and Nickki L Ottaway and David Smiley and Richard D DiMarchi and Diego P{\'e}rez-Tilve},
  journal={Diabetologia},
  year={2015},
  volume={58},
  pages={2124-2132}
}
We assessed the contribution of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) signalling to thermogenesis induced by high-fat diet (HFD) consumption. Furthermore, we determined whether brown adipose tissue (BAT) activity contributes to weight loss induced by chronic subcutaneous treatment with the GLP-1R agonist, liraglutide, in a model of diet-induced obesity. Metabolic phenotyping was performed using indirect calorimetry in wild-type (WT) and Glp1r-knockout (KO) mice during chow and HFD… CONTINUE READING
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