Contribution of brain-derived neurotrophic factor to mechanical hyperalgesia induced by ventral root transection in rats.

@article{Chen2013ContributionOB,
  title={Contribution of brain-derived neurotrophic factor to mechanical hyperalgesia induced by ventral root transection in rats.},
  author={Hui-sheng Chen and Zhong-He Zhou and Man Li and Jian-Xiu Wang and Baojun Liu and Yao Lu},
  journal={Neuroreport},
  year={2013},
  volume={24 4},
  pages={167-70}
}
It is generally believed that the development of neuropathic pain primarily results from injuries to sensory afferent fibers. Recent studies found that injuries to the motor efferent fibers (e.g. ventral root transection) also contribute to the development of neuropathic pain. Furthermore, an increase in brain-derived neurotrophic factor (BDNF) synthesis has been found in the ventral root transection model, suggesting a possible role of BDNF in this model. To determine the role of BDNF, we… CONTINUE READING