Contribution of an additive locus to genetic variance when inheritance is multi-factorial with implications on interpretation of GWAS

@article{Gianola2013ContributionOA,
  title={Contribution of an additive locus to genetic variance when inheritance is multi-factorial with implications on interpretation of GWAS},
  author={Daniel Gianola and F. Hospital and Etienne Verrier},
  journal={Theoretical and Applied Genetics},
  year={2013},
  volume={126},
  pages={1457-1472}
}
Although the effects of linkage disequilibrium (LD) on partition of genetic variance have received attention in quantitative genetics, there has been little discussion on how this phenomenon affects attribution of variance to a given locus. This paper reinforces the point that standard metrics used for assessing the contribution of a locus to variance can be misleading when there is linkage LD and that factors such as distribution of effects and of allelic frequencies over loci, or existence of… CONTINUE READING
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