Contribution of adrenal hormones to nicotine‐induced inhibition of synovial plasma extravasation in the rat

@article{JiaPeiMiao1997ContributionOA,
  title={Contribution of adrenal hormones to nicotine‐induced inhibition of synovial plasma extravasation in the rat},
  author={Frederick Jia‐Pei Miao and Neal L. Benowitz and Philip H. Heller and Jon D. Levine},
  journal={British Journal of Pharmacology},
  year={1997},
  volume={120}
}
In this study, we examined the mechanism(s) by which s.c. nicotine inhibits synovial plasma extravasation. We found that nicotine dose‐dependently inhibited bradykinin (BK)‐ and platelet activating factor (PAF)‐induced plasma extravasation. The effect of nicotine on both BK‐ and PAF‐induced plasma extravasation was attenuated by adrenal medullectomy. ICI‐118,551 (a selective β2‐adrenoceptor blocker) (30 μg ml−1, intra‐articularly) significantly attenuated the inhibitory action of high‐dose (1… Expand
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