Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance.

@article{Powdrill2011ContributionOA,
  title={Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance.},
  author={Megan H. Powdrill and Egor P. Tchesnokov and Robert A Kozak and Rodney S Russell and Ross Martin and Evguenia S Svarovskaia and Hongmei Mo and Roger D. Kouyos and Matthias G{\"o}tte},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 51},
  pages={20509-13}
}
The development of resistance to direct-acting antivirals (DAAs) targeting the hepatitis C virus (HCV) can compromise therapy. However, mechanisms that determine prevalence and frequency of resistance-conferring mutations remain elusive. Here, we studied the fidelity of the HCV RNA-dependent RNA polymerase NS5B in an attempt to link the efficiency of mismatch formation with genotypic changes observed in vivo. Enzyme kinetic measurements revealed unexpectedly high error rates (approximately 10… CONTINUE READING
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References

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Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection

F Kanwal
Gastroenterology 140:1182–1188.e1 • 2011
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