Contribution of Toll-like receptor signaling to germinal center antibody responses.

@article{DeFranco2012ContributionOT,
  title={Contribution of Toll-like receptor signaling to germinal center antibody responses.},
  author={Anthony L DeFranco and Derek C Rookhuizen and Baidong Hou},
  journal={Immunological reviews},
  year={2012},
  volume={247 1},
  pages={64-72}
}
Toll-like receptors (TLRs) have emerged as one of the most important families of innate immune receptors for initiating inflammation and also for promoting adaptive immune responses. Recent studies have examined the ability of TLRs to promote antibody responses, including T-cell-dependent antibody responses. Initial study suggested that TLR stimulation promotes primarily an extrafollicular antibody response, which rapidly produces moderate affinity antibodies made by short-lived plasma cells… CONTINUE READING