Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.

@article{Chen2008ContributionOS,
  title={Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.},
  author={Weijun Chen and Hema Srinath and Suvana S. Lam and Celia A Schiffer and William E. Royer and Kai Lin},
  journal={Journal of molecular biology},
  year={2008},
  volume={379 2},
  pages={251-60}
}
IRF-3, a member of the interferon regulatory factor (IRF) family of transcription factors, functions in innate immune defense against viral infection. Upon infection, host cell IRF-3 is activated by phosphorylation at its seven C-terminal Ser/Thr residues: (385)SSLENTVDLHISNSHPLSLTS(405). This phosphoactivation triggers IRF-3 to react with the coactivators, CREB-binding protein (CBP)/p300, to form a complex that activates target genes in the nucleus. However, the role of each phosphorylation… CONTINUE READING
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