Contribution of SDF-1α/CXCR4 signaling to brain development and glioma progression.

  title={Contribution of SDF-1α/CXCR4 signaling to brain development and glioma progression.},
  author={Zheng Jiang and Wei Zhou and Shanghui Guan and Jianbo Wang and Yemin Liang},
  volume={21 3-4},
The SDF-1α/CXCR4 signaling maintains central nervous system homeostasis through the interaction with the neurotransmitter and neuropeptide systems, the neuroendocrine systems. Recently, the SDF-1α/CXCR4 signaling has been reported to present nonrandom distribution in brain development and glioma progression, which exerts differential regulations on the assembly, differentiation, and function of neural precursors, neurons, glial cells, as well as glioma cells. In the present review, we highlight… CONTINUE READING


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CXCL 12 / CXCR 4 promotes motility and proliferation of glioma cells

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