Contribution of Rho kinase to blood pressure elevation and vasoconstrictor responsiveness in type 2 diabetic Goto-Kakizaki rats.

@article{Rao2013ContributionOR,
  title={Contribution of Rho kinase to blood pressure elevation and vasoconstrictor responsiveness in type 2 diabetic Goto-Kakizaki rats.},
  author={Milly Y Rao and Hesham Soliman and Girish R Bankar and Guorong Lin and Kathleen M Macleod},
  journal={Journal of hypertension},
  year={2013},
  volume={31 6},
  pages={1160-9}
}
OBJECTIVES The RhoA-Rho kinase (ROCK) pathway contributes to a number of diabetic complications including cardiomyopathy and nephropathy. In this study, we investigated whether it contributes to elevated blood pressure and vascular contractile dysfunction in type 2 diabetes. METHODS Blood pressure was measured in Goto-Kakizaki rats, a nonobese model of type 2 diabetes, before and after treatment with the ROCK inhibitor fasudil. Vasoconstrictor responsiveness in the absence and presence of… CONTINUE READING
Highly Cited
This paper has 23 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Assessment of endothelial function of large, medium, and small vessels: a unified myograph.

American journal of physiology. Heart and circulatory physiology • 2011
View 2 Excerpts

Rho kinase inhibition in diabetic nephropathy.

Current opinion in nephrology and hypertension • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…