Contribution of Retrotransposable Elements to Aging

  title={Contribution of Retrotransposable Elements to Aging},
  author={Jill A Kreiling and Brian Christopher Jones and JohnG. Wood and Marco De Cecco and Steven W. Criscione and Nicola Neretti and Stephen L. Helfand and John M. Sedivy},
Retrotransposable elements (RTEs) are abundant in the genomes of most species and continue to evolve and adapt to the defense mechanisms of their host cells. RTEs have contributed to the evolution of their hosts by creating germline genomic diversity, but under most circumstances retrotransposition has deleterious consequences. Our understanding of RTE activity in somatic cells and tissues has lagged, largely because we lacked effective tools to study them in these contexts. Recent evidence… CONTINUE READING
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