Contribution of Reactive Oxygen Species to Isoflurane-induced Sensitization of Cardiac Sarcolemmal Adenosine Triphosphate–sensitive Potassium Channel to Pinacidil

  title={Contribution of Reactive Oxygen Species to Isoflurane-induced Sensitization of Cardiac Sarcolemmal Adenosine Triphosphate–sensitive Potassium Channel to Pinacidil},
  author={Jianzhong An and Anna Stadnicka and Wai-Meng Kwok and Zeljko J Bosnjak},
BackgroundMyocardial protection by volatile anesthetics involves activation of cardiac adenosine triphosphate–sensitive potassium (KATP) channels. The authors have previously shown that isoflurane enhances sensitivity of the sarcolemmal KATP channel to the opener, pinacidil. Because reactive oxygen species seem to be mediators in anesthetic preconditioning, the authors investigated whether they contribute to the mechanism of the sensitization effect by isoflurane. MethodsVentricular myocytes… 

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Isoflurane Sensitizes the Cardiac Sarcolemmal Adenosine Triphosphate–Sensitive Potassium Channel to Pinacidil

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The results suggest that both sarcolemmal and mitochondrial KATP channels could be involved in volatile anesthetic–induced preconditioning, and desflurane reduces myocardial infarct size in vivo.

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Effects of volatile anesthetic isoflurane on ATP-sensitive K+ channels in rabbit ventricular myocytes.

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