Contribution of Reactive Oxygen Species to 3-Hydroxyglutarate Neurotoxicity in Primary Neuronal Cultures from Chick Embryo Telencephalons

@article{Koelker2001ContributionOR,
  title={Contribution of Reactive Oxygen Species to 3-Hydroxyglutarate Neurotoxicity in Primary Neuronal Cultures from Chick Embryo Telencephalons},
  author={Stefan Koelker and Barbara Ahlemeyer and Josef Krieglstein and Georg Friedrich Hoffmann},
  journal={Pediatric Research},
  year={2001},
  volume={50},
  pages={76-82}
}
Glutaryl-CoA dehydrogenase deficiency is an autosomal recessively inherited neurometabolic disorder with a distinct neuropathology characterized by acute encephalopathic crises during a vulnerable period of brain development. 3-Hydroxyglutarate (3-OH-GA), which accumulates in affected patients, has been identified as an endogenous neurotoxin mediating excitotoxicity via N-methyl-d-aspartate receptors. As increased generation of reactive oxygen species (ROS) and nitric oxide (NO) plays an… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references