Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension.

@article{Muthalif2000ContributionOR,
  title={Contribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension.},
  author={Mubarack M. Muthalif and Ibrahim Fadil Benter and Zinat Khandekar and Lillian W. Gaber and Antoinette Estes and Shabnam Malik and J H Parmentier and Veeraswamy Manne and Kafait U. Malik},
  journal={Hypertension},
  year={2000},
  volume={35 1 Pt 2},
  pages={
          457-63
        }
}
We recently reported that norepinephrine and angiotensin II activate the Ras/mitogen-activated protein (MAP) kinase pathway through generation of a cytochrome P450 (CYP450) and lipoxygenase metabolites. The purpose of this study was to determine the contribution of Ras/MAP kinase to deoxycorticosterone acetate (DOCA)-salt-induced hypertension in rats. Administration of DOCA and 1% saline drinking water to uninephrectomized rats for 6 weeks significantly elevated mean arterial blood pressure… CONTINUE READING

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References

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Showing 1-10 of 49 references

20-HETE contributes to the renal vasoconstrictor actions of Ang II

A Alonso-Garcia, AS Greene, TM Kurth, AW Cowley, RJ. Roman
FASEB J. 1999;13:A389. Abstract • 1999

Contribution of Ras GTPase to the development of Ang II-induced hypertension

I Benter, MM Muthalif, N Karzoun, SF Fatima, KU. Malik
FASEB J. 1999;13:A484. Abstract • 1999

20-HETE mediates Ca 21/calmodulin-dependent protein kinase II-induced MAP kinase activation in vascular smooth muscle cells

MM Muthalif, N Karzoun, +3 authors KU. Malik
Proc Natl Acad Sci U S A • 1998

CYP-450 metabolites mediate norepinephrine-induced mitogen signaling. Hypertension

MR Uddin, MM Muthalif, NA Karzoun, IF Benter, KU. Malik
Hypertension January • 1998

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