Contribution of OCTN Variants Within the IBD5 Locus to Pediatric Onset Crohn's Disease

@article{Babusukumar2006ContributionOO,
  title={Contribution of OCTN Variants Within the IBD5 Locus to Pediatric Onset Crohn's Disease},
  author={Umesh Babusukumar and Tao Wang and Erin O McGuire and Ulrich Broeckel and Subra Kugathasan},
  journal={The American Journal of Gastroenterology},
  year={2006},
  volume={101},
  pages={1354-1361}
}
BACKGROUND & AIMS:The IBD5 locus on chromosome 5q31 is a confirmed Crohn's disease (CD) susceptibility locus in adults. Recently, two polymorphisms in the organic cation transporter (OCTN) gene cluster within the IBD5 locus have been found to be associated with CD. Although the original report of significant linkage to IBD5 was in families with at least one case of early age at onset CD, there are no published reports on the role of OCTN genes in pediatric onset CD. We performed a comprehensive… CONTINUE READING
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