Contribution of Nitric Oxide in Big Endothelin-1–induced Cardioprotective Effects on Ischemia/Reperfusion Injury in Rat Hearts

@article{Tawa2011ContributionON,
  title={Contribution of Nitric Oxide in Big Endothelin-1–induced Cardioprotective Effects on Ischemia/Reperfusion Injury in Rat Hearts},
  author={Masashi Tawa and Taiki Fukumoto and Mamoru Ohkita and Naoto Yamashita and Ayman Geddawy and Takeshi Imamura and Kazuhide Ayajiki and Tomio Okamura and Yasuo Matsumura},
  journal={Journal of Cardiovascular Pharmacology},
  year={2011},
  volume={57},
  pages={575-578}
}
We have recently shown that an appropriate amount of exogenous big endothelin-1 (ET-1) has beneficial effects on ischemia-/reperfusion-induced norepinephrine overflow and cardiac dysfunction in rat hearts and that these effects occur through a conversion to ET-1 by endothelin-converting enzyme and following stimulation of ETB receptor. In this study, we examined the possible involvement of nitric oxide (NO) in the big ET-1-induced cardioprotective effects. According to the Langendorff technique… Expand
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