Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons.

@article{Renganathan2001ContributionON,
  title={Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons.},
  author={Muthukrishnan Renganathan and Theodore R. Cummins and Stephen G. Waxman},
  journal={Journal of neurophysiology},
  year={2001},
  volume={86 2},
  pages={629-40}
}
C-type dorsal root ganglion (DRG) neurons can generate tetrodotoxin-resistant (TTX-R) sodium-dependent action potentials. However, multiple sodium channels are expressed in these neurons, and the molecular identity of the TTX-R sodium channels that contribute to action potential production in these neurons has not been established. In this study, we used current-clamp recordings to compare action potential electrogenesis in Na(v)1.8 (+/+) and (-/-) small DRG neurons maintained for 2-8 h in… CONTINUE READING
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