Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia.

@article{Kapetanovic2010ContributionON,
  title={Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia.},
  author={Ronan Kapetanovic and Gr{\'e}gory Jouvion and Catherine Fitting and Marianna Parlato and Charl{\`e}ne Blanchet and Michel Ren{\'e} Huerre and J M Cavaillon and Minou Adib-Conquy},
  journal={Microbes and infection},
  year={2010},
  volume={12 10},
  pages={759-67}
}
Staphylococcus aureus is the most commonly found Gram-positive bacterium in patients admitted in intensive-care units, causing septicaemia or pneumonia. In this work, we investigated the role of NOD2 in S. aureus-induced pneumonia. We found that the absence of NOD2 affected weight loss and recovery speed. Nod2-/- mice showed a reduced lung inflammation in comparison to wild-type animals, with lower presence of cytokines in broncho-alveolar lavage fluids and reduced recruitment of neutrophils… CONTINUE READING